Nabp1^tm1.1Kkha
Targeted Allele Detail

Summary

• Symbol: Nabp1^tm1.1Kkha
• Name: nucleic acid binding protein 1; targeted mutation 1.1, Kum Kum Khanna
• MGI ID: MGI:5644800
• Synonyms: Ssb2^-
• Gene: Nabp1 Location: Chr1:51505021-51517584 bp, - strand Genetic Position: Chr1, 26.58 cM, cytoband C1
• Alliance: Nabp1^tm1.1Kkha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220670
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 has been deleted by Cre recombinase, leaving a single loxP site. A frt-flanked neomycin resistance cassette that was in intron 1, downstream of the 5' loxP site, also has been deleted. Western blot analysis confirmed the absence of encoded protein in the thymus, spleen and testis of homozygous mutant mice. (J:220670)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nabp1 Mutation: 17 strains or lines available

References

• Original: J:220670 Boucher D, et al., Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice. FASEB J. 2015 Aug;29(8):3326-34
• All: 1 reference(s)