Nipbl^{Gt(EUCE313f02)1.2Hmgu}
Gene trapped Allele Detail

Summary

• Symbol: Nipbl^{Gt(EUCE313f02)1.2Hmgu}
• Name: NIPBL cohesin loading factor; gene trap EUCE313f02, 1.2, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5644813
• Synonyms: Nipbl^FIN
• Gene: Nipbl Location: Chr15:8320101-8473947 bp, - strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Nipbl^{Gt(EUCE313f02)1.2Hmgu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236978
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A conditional-ready gene trap cassette with F3, Frt, LoxP, and Lox511 sites flanking a beta-geo reporter was inserted into exon 1 and subsequent Cre- and Flp-mediated excision yielded this allele in which the inverted insertion was re-inverted to the forward orientation on the positive strand so transcription is disrupted resulting in the final null allele configuration. (J:236978)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nipbl Mutation: 124 strains or lines available

References

• Original: J:236978 Santos R, et al., Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197
• All: 3 reference(s)