Tarbp2^tm1.2Dzw
Targeted Allele Detail

Summary

• Symbol: Tarbp2^tm1.2Dzw
• Name: TARBP2, RISC loading complex RNA binding subunit; targeted mutation 1.2, Da-Zhi Wang
• MGI ID: MGI:5645259
• Gene: Tarbp2 Location: Chr15:102426627-102432111 bp, + strand Genetic Position: Chr15, 57.65 cM, cytoband F
• Alliance: Tarbp2^tm1.2Dzw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222613
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin selection cassette with a downstream loxP site was inserted downstream of exon 9 and a loxP site was inserted upstream of exon 3. flp-mediated excision deleted the neomycin selection cassette and subsequent Cre-mediated excision deleted exons 3 through 9 yielding this null allele. (J:222613)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tarbp2 Mutation: 22 strains or lines available

References

• Original: J:222613 Ding J, et al., Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul;47(7):776-83
• All: 2 reference(s)