Kras^tm3Bbd
Targeted Allele Detail

Summary

• Symbol: Kras^tm3Bbd
• Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 3, Mariano Barbacid
• MGI ID: MGI:5645350
• Synonyms: Kras^FSFG12V
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm3Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a FRT site flanked neomycin resistance gene and STOP cassette upstream of the ATG initiation codon into intron 1 and glycine codon 12 (GGT) in exon 2 was changed to valine (GTA) (p.G12V), a mutation commonly found in human tumors. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 84 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 9 reference(s)