Prdm11^tm1.1Ahl
Targeted Allele Detail

Summary

• Symbol: Prdm11^tm1.1Ahl
• Name: PR domain containing 11; targeted mutation 1.1, Anders Henrik Lund
• MGI ID: MGI:5645487
• Synonyms: Prdm11 KO
• Gene: Prdm11 Location: Chr2:92802363-92876512 bp, - strand Genetic Position: Chr2, 51.37 cM
• Alliance: Prdm11^tm1.1Ahl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221379
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 and 3 were flanked by loxP sites via homolgous recombination. These exons were then deleted by crossing to a germline CMV-cre mouse. (J:221379)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Prdm11^tm1.1Ahl/Prdm11^tm1.1Ahl	B6.129(C)-Prdm11^tm1.1Ahl
cx2	Prdm11^tm1.1Ahl/Prdm11^tm1.1Ahl Tg(IghMyc)22Bri/0	B6.Cg-Prdm11^tm1.1Ahl Tg(IghMyc)22Bri

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms
cellular	√
abnormal cell physiology	√
increased megakaryocyte progenitor cell proliferation	√
hematopoietic system	√
increased megakaryocyte progenitor cell proliferation	√
decreased neutrophil cell number	√
increased B cell number	√
decreased CD4-positive, alpha-beta T cell number	√
abnormal hematopoietic precursor cell morphology	√
decreased megakaryocyte progenitor cell number	√
immune system	√
decreased neutrophil cell number	√
increased B cell number	√
decreased CD4-positive, alpha-beta T cell number	√
abnormal humoral immune response	√
increased interferon-gamma secretion	√
increased interleukin-2 secretion	√
neoplasm		√
increased B cell derived lymphoma incidence		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm11 Mutation: 22 strains or lines available

References

• Original: J:221379 Fog CK, et al., Loss of PRDM11 promotes MYC-driven lymphomagenesis. Blood. 2015 Feb 19;125(8):1272-81
• All: 3 reference(s)