Tg(Pten)1Srn
Transgene Detail

Summary

• Symbol: Tg(Pten)1Srn
• Name: transgene insertion 1, Manuel Serrano
• MGI ID: MGI:5645732
• Synonyms: Pten^tg
• Transgene: Tg(Pten)1Srn Location: unknown
• Alliance: Tg(Pten)1Srn page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pten)1Srn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pten (MGI:109583)

• Mutation details: Transgenesis was performed using a BAC, RP24-372O16, that includes the complete mouse gene. One line was selected for further analysis that expresses ~2-fold (2.3+/-0.4) the level of Pten mRNA relative to their control littermates across all examined tissues, including brain, heart, liver, lung, kidney, skin, muscle, brown adipose tissue (BAT), and white adipose tissue (WAT), as well as in mouse embryonic fibroblasts (MEFs). (J:182671)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:182671 Ortega-Molina A, et al., Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 2012 Mar 7;15(3):382-94
• All: 8 reference(s)