Ddt^tm1Lhy
Targeted Allele Detail

Summary

• Symbol: Ddt^tm1Lhy
• Name: D-dopachrome tautomerase; targeted mutation 1, Lawrence H Young
• MGI ID: MGI:5645788
• Synonyms: Ddt^fl
• Gene: Ddt Location: Chr10:75607067-75609208 bp, - strand Genetic Position: Chr10, 38.58 cM
• Alliance: Ddt^tm1Lhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213776
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked puro cassette and loxP site were inserted downstream of exon 2 via homologous recombination. (J:213776)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddt Mutation: 14 strains or lines available

References

• Original: J:213776 Qi D, et al., The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury. J Clin Invest. 2014 Aug 1;124(8):3540-50
• All: 2 reference(s)