Prickle1^tm1.3Asw
Targeted Allele Detail

Summary

• Symbol: Prickle1^tm1.3Asw
• Name: prickle planar cell polarity protein 1; targeted mutation 1.3, Anand Swaroop
• MGI ID: MGI:5645933
• Synonyms: Prickle1^c, Prickle1^f
• Gene: Prickle1 Location: Chr15:93396995-93493772 bp, - strand Genetic Position: Chr15, 47.69 cM
• Alliance: Prickle1^tm1.3Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213772
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT site, splice acceptor, EYFP, loxP site, neomycin resistance (neo) cassette, FRT site and loxP site were inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp mediated recombination removed the EYFP and neo cassette leaving exon 2 floxed. (J:213772)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prickle1 Mutation: 34 strains or lines available

References

• Original: J:213772 Liu C, et al., Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3(9):861-70
• All: 2 reference(s)