Gpr107^tm1Brs
Targeted Allele Detail

Summary

• Symbol: Gpr107^tm1Brs
• Name: G protein-coupled receptor 107; targeted mutation 1, Brian Seed
• MGI ID: MGI:5645975
• Synonyms: Gpr107^-
• Gene: Gpr107 Location: Chr2:31042099-31106579 bp, + strand Genetic Position: Chr2, 21.8 cM
• Alliance: Gpr107^tm1Brs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215242
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1-13 along with a 2-kb upstream region were replaced with a R4 integrase attB- and attP- flanked neomycin cassette. The neomycin cassette was then removed by transient expression of R4 integrase in the targeted clones. RT-PCR analysis confirmed absence of mRNA expression in E10.5 homozygous mutant embryos and yolk-sac tissues. (J:215242)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr107 Mutation: 125 strains or lines available

References

• Original: J:215242 Zhou GL, et al., Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption. J Cell Sci. 2014 Sep 15;127(Pt 18):3916-27
• All: 1 reference(s)