Srxn1^tm1Sgrh
Targeted Allele Detail

Summary

• Symbol: Srxn1^tm1Sgrh
• Name: sulfiredoxin 1 homolog (S. cerevisiae); targeted mutation 1, Sue Goo Rhee
• MGI ID: MGI:5646116
• Synonyms: Srx^flox
• Gene: Srxn1 Location: Chr2:151947436-151953296 bp, + strand Genetic Position: Chr2, 74.83 cM, cytoband H1
• Alliance: Srxn1^tm1Sgrh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222986
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. (J:222986)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srxn1 Mutation: 9 strains or lines available

References

• Original: J:222986 Kil IS, et al., Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria. Mol Cell. 2012 Jun 8;46(5):584-94
• All: 3 reference(s)