Abcc9^tm1.1Mcn
Targeted Allele Detail

Summary

• Symbol: Abcc9^tm1.1Mcn
• Name: ATP-binding cassette, sub-family C member 9; targeted mutation 1, Elizabeth M McNally
• MGI ID: MGI:5646147
• Gene: Abcc9 Location: Chr6:142533588-142648041 bp, - strand Genetic Position: Chr6, 74.35 cM
• Alliance: Abcc9^tm1.1Mcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216539
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites and a neomycin selection cassette were inserted into the flanking regions of exon 5. Mice heterozygous for the targeted allele were crossed with protamine-Cre transgenic mice to remove the neomycin cassette and exon 5. Deletion of exon 5 induced a frameshift and disrupted expression of the encoded protein. Expression of both the long form and the short form of the encoded protein was affected. (J:216539)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc9 Mutation: 101 strains or lines available

References

• Original: J:216539 Fahrenbach JP, et al., Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J. 2014 Jul;28(7):2804-15
• All: 1 reference(s)