Pik3cb^tm1.1Jdo
Targeted Allele Detail

Summary

• Symbol: Pik3cb^tm1.1Jdo
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1.1,Julian Downward
• MGI ID: MGI:5646522
• Synonyms: p110beta-RBD-DM
• Gene: Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Pik3cb^tm1.1Jdo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: S205D (AGT->GAT) and K224A (AAA->GCA) point mutations were introduced to the catalytic subunit of the gene and an FRT-flanked neomycin selection cassette was inserted in intron 6. The neomycin selection cassette was excised through crosses with Tg(ACTFLPe)9205Dym deleter mice, leaving a single FRT site in intron 6/7. (J:198414)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3cb Mutation: 152 strains or lines available

References

• Original: J:198414 Fritsch R, et al., RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell. 2013 May 23;153(5):1050-63
• All: 2 reference(s)