Mc4r^{tm3.1(cre)Lowl}
Targeted Allele Detail

Summary

• Symbol: Mc4r^{tm3.1(cre)Lowl}
• Name: melanocortin 4 receptor; targeted mutation 3.1, Bradford B Lowell
• MGI ID: MGI:5647881
• Synonyms: mc4r-t2a-cre
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^{tm3.1(cre)Lowl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222852
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mc4r^{tm3.1(cre)Lowl} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mc4r (MGI:99457)

• Mutation details: A t2a cleaving peptide from Thosea asigna virus and a cre recombinase gene were inserted downstream of the stop codon. (J:222852)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mc4r (mouse) Summary of all recombinase alleles driven by Mc4r. Comparative matrix view of recombinase activities Alliance mouse Mc4r gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 48 strains or lines available

References

• Original: J:222852 Garfield AS, et al., A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Jun;18(6):863-71
• All: 24 reference(s)