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Tg(SFTPC*)#Twv
Transgene Detail
Summary
Symbol: Tg(SFTPC*)#Twv
Name: transgene insertion, Timothy E Weaver
MGI ID: MGI:5647890
Synonyms: SP-Cdeltaexon4
Transgene: Tg(SFTPC*)#Twv  Location: unknown  
Alliance: Tg(SFTPC*)#Twv page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SFTPC*)#Twv expresses 1 gene
 
Mutation detailsA human SP-C delta exon4 cDNA was generated by deleting nucleotides 325435 (adenosine of start ATG is base pair 1). A transgene construct was generated by subcloning the human SP-C delta exon4 cDNA into a vector containing the 13-kb mouse SP-C promoter, a rabbit globin intronic/exonic sequences, and a bovine growth hormone polyadenylation signal. Two founder mice were generated but did not survive. (J:87084)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Two founder mice were generated but did not survive. No lines were established. The phenotypes of the founder mice are reported. Severity of the phenotype was correlated with the expression level of the mutated protein.
References
Original:  J:87084 Bridges JP, et al., Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice. J Biol Chem. 2003 Dec 26;278(52):52739-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory