b2b3121Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b3121Clo
• Name: Mutant line 3121 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 3121 Cecilia Lo
• MGI ID: MGI:5647996
• Synonyms: ET
• Gene: b2b3121Clo Location: unknown
• Alliance: b2b3121Clo page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See Wrn^b2b3121.1Clo and b2b3121.2Clo. (J:175213)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any b2b3121Clo Mutation: 0 strains or lines available

Notes

Summative Diagnosis:
Mutant Type 1:
Cardiovascular phenotypes: outflow anomaly comprising of bicuspic aortic or pulmonary valves.

Noncardiovascular phenotype: cleft palate, hypoplastic thymus, enlarged adrenal gland


Mutant Type 2:
Noncardiovascular phenotype: Hydrocephalus with possible cerebral arteriovenous malformation - (Vein of Galen)

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)