Pde4b^enu1H
Chemically induced Allele Detail

Summary

• Symbol: Pde4b^enu1H
• Name: phosphodiesterase 4B, cAMP specific; mutation 1, Harwell
• MGI ID: MGI:5648042
• Synonyms: Pde4b^m1H, Pde4b^Y358C
• Gene: Pde4b Location: Chr4:101944740-102464456 bp, + strand Genetic Position: Chr4, 46.99 cM
• Alliance: Pde4b^enu1H page

Mutation origin

• Strain of Origin: BALB/cAnN

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an adenine to guanine (A1073G) transition in exon 10 that results in the amino acid substitution of cysteine for tyrosine at position 358 (Y358C). (J:223217)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pde4b Mutation: 55 strains or lines available

References

• Original: J:223217 McGirr A, et al., Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition. Neuropsychopharmacology. 2016 Mar;41(4):1080-92
• All: 2 reference(s)