Hnrnpu^tm1.1Tman
Targeted Allele Detail

Summary

• Symbol: Hnrnpu^tm1.1Tman
• Name: heterogeneous nuclear ribonucleoprotein U; targeted mutation 1.1, Tom Maniatis
• MGI ID: MGI:5648110
• Synonyms: Hnrnpu f
• Gene: Hnrnpu Location: Chr1:178148673-178165362 bp, - strand Genetic Position: Chr1, 83.16 cM
• Alliance: Hnrnpu^tm1.1Tman page

Aberrant cardiomyocyte oranization and contractility in Hnrnpu^tm1.1Tman/Hnrnpu^tm1.1Tman Tg(Ckmm-cre)5Khn/0 hearts

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223139
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 14. Cre-mediated recombination removed the selection cassette and left exons 4 through 14 floxed. (J:223139)

Generation of the Hnrnpu^tm1.1Tman allele

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hnrnpu Mutation: 43 strains or lines available

References

• Original: J:223139 Ye J, et al., hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9
• All: 5 reference(s)