Tg(tetO-Hgf,-EGFP)24Tcre
Transgene Detail

Summary

• Symbol: Tg(tetO-Hgf,-EGFP)24Tcre
• Name: transgene insertion 24, Tiziana Crepaldi
• MGI ID: MGI:5648118
• Synonyms: HGF-TRE-EGFP responder, Tg(tetO-Hgf,-EGFP)Tcre
• Transgene: Tg(tetO-Hgf,-EGFP)24Tcre Location: unknown
• Alliance: Tg(tetO-Hgf,-EGFP)24Tcre page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Hgf,-EGFP)24Tcre expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hgf (MGI:96079)

• Mutation details: The mouse HGF cDNA was inserted in the bidirectional pBI TRE response plasmid containing enhanced green fluorescent protein (EGFP) as a reporter gene. Five transgenic founders were obtained. Fibroblasts from line 24 expressed GFP upon infection with LV-TA1 lentiviral vector carrying tTA under the phosphoglycerate kinase promoter; this line was expanded and studied further. (J:223066)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:223066 Riess I, et al., A mouse model for spatial and temporal expression of HGF in the heart. Transgenic Res. 2011 Dec;20(6):1203-16
• All: 3 reference(s)