Mir18^tm1.1Aven
Targeted Allele Detail

Summary

• Symbol: Mir18^tm1.1Aven
• Name: microRNA 18; targeted mutation 1.1, Andrea Ventura
• MGI ID: MGI:5648414
• Synonyms: miR17~92delta18
• Gene: Mir18 Location: Chr14:115281283-115281378 bp, + strand Genetic Position: Chr14, 59.4 cM
• Alliance: Mir18^tm1.1Aven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223213
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Mir18 within the Mirc1 cluster was replaced by an FRT-flanked neomycin cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:223213)

Expression

In Mice Carrying this Mutation:

156054 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir18 Mutation: 2 strains or lines available

References

• Original: J:223213 Han YC, et al., An allelic series of miR-17 approximately 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jul;47(7):766-75
• All: 2 reference(s)