Mirc1^tm4.1Aven
Targeted Allele Detail

Summary

• Symbol: Mirc1^tm4.1Aven
• Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 4.1, Andrea Ventura
• MGI ID: MGI:5648475
• Synonyms: miR-17~92 delta17,18,92
• Gene: Mirc1 Location: Chr14:115281103-115281938 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223213
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mirc1^tm4.1Aven involves 3 genes/genome features (Mir17, Mir18, Mir92-1) View all
• Mutation details: The Mir17, Mir18 and Mir92-1 genes were replaced by an FRT-flanked neomycin cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:223213)

Expression

In Mice Carrying this Mutation:	156054 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc1 Mutation: 6 strains or lines available

References

• Original: J:223213 Han YC, et al., An allelic series of miR-17 approximately 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jul;47(7):766-75
• All: 1 reference(s)