Mirc32^tm1.2Jtm
Targeted Allele Detail

Summary

• Symbol: Mirc32^tm1.2Jtm
• Name: microRNA cluster 32, including Mir143 and Mir145a; targeted mutation 1.2, Joshua T Mendell
• MGI ID: MGI:5648485
• Synonyms: miR-143/145^null, miR^null
• Gene: Mirc32 Location: Chr18:61780896-61782329 bp Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214382
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted upstream of Mir143 and an FRT flanked neo cassette and loxP site were inserted downstream of Mir145a via homologous recombination. Recombinase mediated recombination removed the neo cassette and both microRNAs. (J:214382)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc32 Mutation: 3 strains or lines available

References

• Original: J:214382 Chivukula RR, et al., An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell. 2014 May 22;157(5):1104-16
• All: 1 reference(s)