Tg(tetO-Kras*G12D)#Rdp
Transgene Detail

Summary

• Symbol: Tg(tetO-Kras*G12D)#Rdp
• Name: transgene insertion, Ronald DePinho
• MGI ID: MGI:5648530
• Synonyms: TetO_LKras^G12D, tetO_Lox-Stop-Lox-Kras^G12D
• Transgene: Tg(tetO-Kras*G12D)#Rdp Location: unknown
• Alliance: Tg(tetO-Kras*G12D)#Rdp page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Kras*G12D)#Rdp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kras (MGI:96680)

• Mutation details: The murine Kras containing the G12D mutation is under the control of the tet-operator with a lox-stop-lox cassette inserted between the promoter and the start codon of the Kras open reading frame. Expression of the mutant Kras is dependent on Cre-mediated deletion of the stop cassette. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:186194)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-Kras*G12D)#Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186194 Ying H, et al., Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Apr 27;149(3):656-70
• All: 11 reference(s)