Spon1^tm1Gdpa
Targeted Allele Detail

Summary

• Symbol: Spon1^tm1Gdpa
• Name: spondin 1, (f-spondin) extracellular matrix protein; targeted mutation 1, Glyn D Palmer
• MGI ID: MGI:5648858
• Gene: Spon1 Location: Chr7:113365235-113642605 bp, + strand Genetic Position: Chr7, 59.25 cM
• Alliance: Spon1^tm1Gdpa page

Spon1^tm1Gdpa/Spon1^tm1Gdpa mice exhibit post-natal accumulation of bone

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214251
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The first coding exon was replaced with an IRES/betaGeo/PolyA cassette via homologous recombination. RT-PCR analysis confirmed the absence of expression in multiple tissues from homozygous mice. (J:214251)

Generation of the Spon1^tm1Gdpa allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spon1 Mutation: 33 strains or lines available

References

• Original: J:214251 Palmer GD, et al., F-spondin deficient mice have a high bone mass phenotype. PLoS One. 2014;9(5):e98388
• All: 1 reference(s)