Nxf7^tm1.1Froy
Targeted Allele Detail

Summary

• Symbol: Nxf7^tm1.1Froy
• Name: nuclear RNA export factor 7; targeted mutation 1.1, Guy Froyen
• MGI ID: MGI:5649077
• Gene: Nxf7 Location: ChrX:134480304-134499526 bp, - strand Genetic Position: ChrX, 57.25 cM, cytoband F1
• Alliance: Nxf7^tm1.1Froy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. A second loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the yolk sac. (J:200621)

Expression

In Mice Carrying this Mutation:

5 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nxf7 Mutation: 8 strains or lines available

References

• Original: J:200621 Vanmarsenille L, et al., Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. PLoS One. 2013;8(5):e64144
• All: 2 reference(s)