Atp6v1g2^tm1.1Ywd
Targeted Allele Detail

Summary

• Symbol: Atp6v1g2^tm1.1Ywd
• Name: ATPase, H+ transporting, lysosomal V1 subunit G2; targeted mutation 1.1, Yoh Wada
• MGI ID: MGI:5649304
• Gene: Atp6v1g2 Location: Chr17:35453910-35457743 bp, + strand Genetic Position: Chr17, 18.6 cM, cytoband B2
• Alliance: Atp6v1g2^tm1.1Ywd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224136
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT- and loxP flanked neomycin resistance cassette was inserted upstream of exon 2. A third loxP site was inserted downstream of the coding sequence in exon 3. Cre-mediated recombination removed the selection cassette, exon 2 and the coding sequence in exon 3. Western blot analysis confirmed the absence of protein expression in the brain. (J:224136)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp6v1g2 Mutation: 17 strains or lines available

References

• Original: J:224136 Kawamura N, et al., Loss of G2 subunit of vacuolar-type proton transporting ATPase leads to G1 subunit upregulation in the brain. Sci Rep. 2015 Sep 10;5:14027
• All: 1 reference(s)