Sorcs2^tm1Anyk
Targeted Allele Detail

Summary

• Symbol: Sorcs2^tm1Anyk
• Name: sortilin-related VPS10 domain containing receptor 2; targeted mutation 1, Anders Nykjaer
• MGI ID: MGI:5649357
• Gene: Sorcs2 Location: Chr5:36174524-36555483 bp, - strand Genetic Position: Chr5, 19.14 cM
• Alliance: Sorcs2^tm1Anyk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214739
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/SvEmcTer

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 15 was disrupted by insertion of and IRES, lacZ, neo cassette via homologous recombination. Western blot and immunofluorescence analysis confirmed disruption of expression in neurons of the central and peripheral nervous system. (J:214739)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorcs2 Mutation: 72 strains or lines available

Notes

ES cell line = ICp4 in J:214739

References

• Original: J:214739 Glerup S, et al., SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
• All: 9 reference(s)