Hmox1^tm1.1Hes
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1.1Hes
• Name: heme oxygenase 1; targeted mutation 1.1, Harald Esterbauer
• MGI ID: MGI:5649369
• Synonyms: HO-1^fl
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1.1Hes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:214639)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 35 strains or lines available

References

• Original: J:214639 Jais A, et al., Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell. 2014 Jul 3;158(1):25-40
• All: 10 reference(s)