Siva1^tm1.1Att
Targeted Allele Detail

Summary

• Symbol: Siva1^tm1.1Att
• Name: SIVA1, apoptosis-inducing factor; targeted mutation 1.1, Laura D Attardi
• MGI ID: MGI:5659562
• Synonyms: Siva^fl
• Gene: Siva1 Location: Chr12:112611262-112615586 bp, + strand Genetic Position: Chr12, 61.2 cM, cytoband F2
• Alliance: Siva1^tm1.1Att page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223572
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector is designed to insert a single loxP upstream of exon 1, and a loxP-flanked puromycin resistance (puro) cassette site downstream of exon 4 of the SIVA1, apoptosis-inducing factor (Siva1) gene. Cre-mediated recombination removed the floxed puro cassette leaving exons 1-4 floxed. (J:223572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Siva1 Mutation: 17 strains or lines available

References

• Original: J:223572 Van Nostrand JL, et al., The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development. Cancer Discov. 2015 Jun;5(6):622-35
• All: 1 reference(s)