Tasor^MommeD20
Chemically induced Allele Detail

Summary

• Symbol: Tasor^MommeD20
• Name: transcription activation suppressor; modifier of murine metastable epialleles, D20
• MGI ID: MGI:5659903
• Gene: Tasor Location: Chr14:27150791-27205512 bp, + strand Genetic Position: Chr14, 16.51 cM, cytoband B
• Alliance: Tasor^MommeD20 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Mice carrying Tg(Hba1-Gfp)1Ew were treated with ENU. A single base pair, T to C mutation, was detected in intron 1 at the a canonical splice site for exon 1/intron 1. Both the wild-type and a higher molecular weight mutant PCR product are detected in heterozygous mice. The aberrant splice product results in the incorporation of an additional 1,160 nucleotides. The resulting protein is predicted to incorporate 79 additional amino acids followed by a premature stop codon and be subject to nonsense mediated decay. Western blot analysis of testis lysates from heterozygous mice revealed reduced protein expression. (J:99816, J:216844)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tasor Mutation: 93 strains or lines available

References

• Original: J:216844 Harten SK, et al., The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Mamm Genome. 2014 Aug;25(7-8):293-303
• All: 3 reference(s)