Tg(CAG-HPV16E6E7,-luc)#Mspi
Transgene Detail

Summary

• Symbol: Tg(CAG-HPV16E6E7,-luc)#Mspi
• Name: transgene insertion, Michael Spiotto
• MGI ID: MGI:5659908
• Synonyms: iHPV-Luc
• Transgene: Tg(CAG-HPV16E6E7,-luc)#Mspi Location: unknown
• Alliance: Tg(CAG-HPV16E6E7,-luc)#Mspi page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: This transgene consists of the CAG promoter , a loxP flanked EGFP reporter gene, the human papillomavirus 16 (HPV-16) E6 and E7 genes, an IRES, and the luciferase gene. In the absence of Cre recombinase, the EGFP is expressed and prevents the expression of HPV-16 and luciferase. When the floxed EGFP is removed via Cre-mediated recombination, expression of HPV and luciferase are induced. (J:210533)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:210533 Zhong R, et al., Bioluminescent imaging of HPV-positive oral tumor growth and its response to image-guided radiotherapy. Cancer Res. 2014 Apr 1;74(7):2073-81
• All: 2 reference(s)