Cdh5^{tm1(cre/Esr1*)Nat}
Targeted Allele Detail

Summary

• Symbol: Cdh5^{tm1(cre/Esr1*)Nat}
• Name: cadherin 5; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:5660289
• Synonyms: Cdh5-IRES-MCreM
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^{tm1(cre/Esr1*)Nat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cdh5^{tm1(cre/Esr1*)Nat} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdh5 (MGI:105057)

• Mutation details: A construct consisting of an IRES-Mer-cre-Mer was inserted into the 3' UTR via homologous recombination. Mer is a mutated mouse estrogen receptor that sequesters cre to the cytoplasm. (J:215763)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (mouse) Summary of all recombinase alleles driven by Cdh5. Alliance mouse Cdh5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

References

• Original: J:215763 Zhou Y, et al., Canonical WNT signaling components in vascular development and barrier formation. J Clin Invest. 2014 Sep 2;124(9):3825-46
• All: 1 reference(s)