Tg(Myh6-Jup*)1Ajm
Transgene Detail

Summary

• Symbol: Tg(Myh6-Jup*)1Ajm
• Name: transgene insertion 1, Ali J Marian
• MGI ID: MGI:5660496
• Synonyms: PG^TR
• Transgene: Tg(Myh6-Jup*)1Ajm Location: unknown
• Alliance: Tg(Myh6-Jup*)1Ajm page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Jup*)1Ajm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Jup (MGI:96650)

• Mutation details: A truncated murine plakoglobin gene is under the control of the cardiac-restricted alpha-myosin heavy chain promoter. To generate the truncated gene, a 2 base pair deletion was introduced which causes a frameshift at the 3' end of the Jup gene and introduces 11 new amino acids, and a stop codon was introduced after the 11 new amino acids. Three lines were generated: 1, 2, and 3. Line 1 is the high-expressing line. (J:192719)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:192719 Lombardi R, et al., Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res. 2011 Dec 9;109(12):1342-53
• All: 3 reference(s)