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Bcat1tm1.2Eaa
Targeted Allele Detail
Summary
Symbol: Bcat1tm1.2Eaa
Name: branched chain aminotransferase 1, cytosolic; targeted mutation 1.2, Elitsa A Ananieva
MGI ID: MGI:5660825
Gene: Bcat1  Location: Chr6:144939561-145021883 bp, - strand  Genetic Position: Chr6, 77.27 cM
Alliance: Bcat1tm1.2Eaa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216027
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.5 kb genomic region including exon 6 was flanked with loxP sites and a floxed neo cassette was inserted via homologous recombination. Cre mediated recombination removed the neo cassette and exon 6. Western blot analysis confirmed the absence of protein expression in brains of homozygous mice. (J:216027)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcat1 Mutation:  166 strains or lines available
References
Original:  J:216027 Ananieva EA, et al., Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells. J Biol Chem. 2014 Jul 4;289(27):18793-804
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory