Rack1^tm1Sbif
Targeted Allele Detail

Summary

• Symbol: Rack1^tm1Sbif
• Name: receptor for activated C kinase 1; targeted mutation 1, Stefano Biffo
• MGI ID: MGI:5660834
• Synonyms: deltaF
• Gene: Rack1 Location: Chr11:48691187-48697068 bp, + strand Genetic Position: Chr11, 28.77 cM
• Alliance: Rack1^tm1Sbif page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223207
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Aberrant integration of a targeting construct resulted in a 142 nucleotide deletion in intron 2 and insertion of a loxP-flanked Neo cassette in intron 3 of the gene. This mutation resulted in hypomorphic expression of the gene. (J:223207)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rack1 Mutation: 56 strains or lines available

References

• Original: J:223207 Volta V, et al., RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency. Cell Mol Life Sci. 2013 Apr;70(8):1439-50
• All: 1 reference(s)