Or8a1^{tm42(Mc4r)Mom}
Targeted Allele Detail

Summary

• Symbol: Or8a1^{tm42(Mc4r)Mom}
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 42, Peter Mombaerts
• MGI ID: MGI:5661034
• Synonyms: Mc4r->M71-IRES-tauGFP
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^{tm42(Mc4r)Mom} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260975
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Or8a1^{tm42(Mc4r)Mom} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mc4r (MGI:99457)

• Mutation details: The endogenous coding sequence was replaced by the sequence encoding amoino acids 1 through 333 of Mc4r followed by an IRES-tauGFP cassette for bicistronic expression. The ACNf neomycin selection cassette was self-excised by Cre recombination in the germline of the male chimera. (J:260975)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:260975 Katidou M, et al., G-protein coupled receptors Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons. Mol Cell Neurosci. 2018 Apr;88:138-147
• All: 1 reference(s)