Nphs1^tm1Afrn
Targeted Allele Detail

Summary

• Symbol: Nphs1^tm1Afrn
• Name: nephrosis 1, nephrin; targeted mutation 1, Alessia Fornoni
• MGI ID: MGI:5661391
• Synonyms: NP^flox
• Gene: Nphs1 Location: Chr7:30157740-30186648 bp, + strand Genetic Position: Chr7, 18.36 cM, cytoband A3
• Alliance: Nphs1^tm1Afrn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261848
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert one loxP site upstream of exon 1B, one loxP site upstream of exon 1A, and an FRT-flanked polyA site and a neomycin resistance (neo) cassette followed by a third loxP site downstream of exon 5. (J:261848)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nphs1 Mutation: 70 strains or lines available

References

• Original: J:261848 Villarreal R, et al., Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor. J Am Soc Nephrol. 2016 Apr;27(4):1029-41
• All: 2 reference(s)