Zfpm2^tm1.1Esv
Targeted Allele Detail

Summary

• Symbol: Zfpm2^tm1.1Esv
• Name: zinc finger protein, multitype 2; targeted mutation 1.1, Eric C Svensson
• MGI ID: MGI:5661400
• Synonyms: FOG-2^R3K5A
• Gene: Zfpm2 Location: Chr15:40518438-40967988 bp, + strand Genetic Position: Chr15, 15.74 cM, cytoband C
• Alliance: Zfpm2^tm1.1Esv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: R3A and K5A mutations were inserted in exon 1 and a floxed neo cassette was inserted into intron 1 via homologous recombination. The mutation in exon 1 disrupts interaction of the protein with subunits of the nucleosome remodeling and histone deacetylase complex. Cre mediated recombination removed the neo cassette. Western blot analysis of E13.5 heart lysates revealed comparable protein levels in wild-type, heterozygous, and homozygous mutant hearts. (J:216295)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfpm2 Mutation: 47 strains or lines available

Notes

AA- p.Asn3Ala, p.Lys5Ala

References

• Original: J:216295 Garnatz AS, et al., FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol. 2014 Nov 1;395(1):50-61
• All: 1 reference(s)