Hspbp1^tm1Jhoh
Targeted Allele Detail

Summary

• Symbol: Hspbp1^tm1Jhoh
• Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; targeted mutation 1, Jorg Hohfeld
• MGI ID: MGI:5661504
• Gene: Hspbp1 Location: Chr7:4663520-4688067 bp, - strand Genetic Position: Chr7, 2.69 cM, cytoband A1
• Alliance: Hspbp1^tm1Jhoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216246
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 including part of the promoter region were replaced with a mouse Hprt minigene via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in tissues from homozygous mice. (J:216246)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspbp1 Mutation: 27 strains or lines available

References

• Original: J:216246 Rogon C, et al., HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell. 2014 Aug 1;25(15):2260-71
• All: 2 reference(s)