Lyst^bg-18J
Spontaneous Allele Detail

Summary

• Symbol: Lyst^bg-18J
• Name: lysosomal trafficking regulator; beige 18 Jackson
• MGI ID: MGI:5661588
• Gene: Lyst Location: Chr13:13764982-13953388 bp, + strand Genetic Position: Chr13, 5.28 cM
• Alliance: Lyst^bg-18J page

Mutation origin

• Strain of Origin: BKS.Cg-Dock7^m +/+ Lepr^db/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: A spontaneous G-to-A point transition in the fifth base of intron 10 near the splice donor site is predicted to cause skipping of exon 10 and a frameshift that creates a premature stop codon. (J:222308)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyst Mutation: 225 strains or lines available

References

• Original: J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
• All: 2 reference(s)