Berr5^BALB/c
QTL Variant Detail

Summary

• QTL variant: Berr5^BALB/c
• Name: berghei resistance locus 5; BALB/c
• MGI ID: MGI:5661592
• QTL: Berr5 Location: unknown Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:163229

Linkage analysis was performed on 257 (C57BL/6 BALB/c)F2 intercross mice using 252 markers to identify QTL associated with susceptibility to Cerebral malaria (survival time).

QTL Berr5 maps to 29.3 - 41.3 Mb on Chromosome 19 with a peak LOD score of 4.69 at 32.3 Mb in linkage with Cerebral malaria susceptibility. C57BL/6 alleles convey susceptiblity to Cerebral malaria, with the majority of animals dying during the early cerebral phase of infection. Conversely, BALB/c mice were resistant to PbA-induced CM, with >75-80% of the animals surviving the cerebral phase. BALB/c alleles convey increased survival through the cerebral phase of infection but have no quantitative effect on parasitemia during the later, anemic phase.

References

• Original: J:163229 Berghout J, et al., Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Genes Immun. 2010 Jun;11(4):310-8
• All: 1 reference(s)