Tg(SFTPC-KIF5B/RET)1Tkoh
Transgene Detail

Summary

• Symbol: Tg(SFTPC-KIF5B/RET)1Tkoh
• Name: transgene insertion 1, Takashi Kohno
• MGI ID: MGI:5661918
• Synonyms: KIF5B-RET
• Transgene: Tg(SFTPC-KIF5B/RET)1Tkoh Location: unknown
• Alliance: Tg(SFTPC-KIF5B/RET)1Tkoh page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-KIF5B/RET)1Tkoh expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KIF5B (3799)

  Kif5b

  (MGI:1098268)

  human

  RET (5979)

  Ret	(MGI:97902)

• Mutation details: The human KIF5B-RET fusion cDNA bearing a FLAG-tag at the N-terminus is under the control of a type 2 alveolar epithelium-specific surfactant protein C promoter. RT-PCR and Western blot analysis confirmed expression of the fusion mRNA and protein in the lungs. This line carries approximately six copies of the transgene. (J:215989)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:215989 Saito M, et al., A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. Carcinogenesis. 2014 Nov;35(11):2452-6
• All: 1 reference(s)