Ylpm1tm1b(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Ylpm1tm1b(KOMP)Wtsi |
Name: |
YLP motif containing 1; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5661980 |
Synonyms: |
Ylpm1- |
Gene: |
Ylpm1 Location: Chr12:85043095-85117289 bp, + strand Genetic Position: Chr12, 39.5 cM, cytoband D3
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Alliance: |
Ylpm1tm1b(KOMP)Wtsi page
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IMPC: |
Ylpm1 gene page |
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Ylpm1tm1b(KOMP)Wtsi/Ylpm1tm1b(KOMP)Wtsi mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.
Show the 1 phenotype image(s) involving this allele.
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Mutant Cell Line: |
EPD0271_5_H05 |
Germline Transmission: |
Earliest citation of germline transmission:
J:188991
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 85059342 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycinunder the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of the targeted exon(s) at position 85062485. The critical exon(s) were thus flanked by loxP sites and subsequent Cre-mediated excision deleted the critical sequence and neomycin selection cassette yielding this knockout reporter allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:148605, J:173534, J:188991)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
6 reference(s) |
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