Rasa1^tm2.1Pdk
Targeted Allele Detail

Summary

• Symbol: Rasa1^tm2.1Pdk
• Name: RAS p21 protein activator 1; targeted mutation 2.1, Philip D King
• MGI ID: MGI:5661985
• Synonyms: Rasa1^R780Q
• Gene: Rasa1 Location: Chr13:85362899-85437249 bp, - strand Genetic Position: Chr13, 45.05 cM
• Alliance: Rasa1^tm2.1Pdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216433
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An R780Q mutation was inserted in exon 18 and an FRT flanked neo cassette was inserted in intron 18 via homologous recombination. Flp mediated recombination removed the neo cassette. This mutation is predicted to abrogate the ability of the protein to promote RAS hydrolysis of bound GTP. (J:216433)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasa1 Mutation: 34 strains or lines available

References

• Original: J:216433 Lubeck BA, et al., Blood Vascular Abnormalities in Rasa1(R780Q) Knockin Mice: Implications for the Pathogenesis of Capillary Malformation-Arteriovenous Malformation. Am J Pathol. 2014 Dec;184(12):3163-9
• All: 4 reference(s)