Chrna7^{tm2.1(cre)Swr}
Targeted Allele Detail

Summary

• Symbol: Chrna7^{tm2.1(cre)Swr}
• Name: cholinergic receptor, nicotinic, alpha polypeptide 7; targeted mutation 2.1, Scott W Rogers
• MGI ID: MGI:5662228
• Synonyms: Chrna7-IRES-Cre
• Gene: Chrna7 Location: Chr7:62748440-62862274 bp, - strand Genetic Position: Chr7, 34.47 cM
• Alliance: Chrna7^{tm2.1(cre)Swr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223063
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Chrna7^{tm2.1(cre)Swr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Chrna7 (MGI:99779)

• Mutation details: The stop codon was replaced with a hemagglutinin (HA) epitope tag (YPYDVPDY), IRES, cre recombinase gene and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:223063)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Chrna7 (mouse) Summary of all recombinase alleles driven by Chrna7. Comparative matrix view of recombinase activities Alliance mouse Chrna7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna7 Mutation: 50 strains or lines available

References

• Original: J:223063 Rogers SW, et al., Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. Am J Med Genet A. 2012 May;158A(5):1135-44
• All: 4 reference(s)