Tg(HCRT-EGFP,-cre)1Ahky
Transgene Detail

Summary

• Symbol: Tg(HCRT-EGFP,-cre)1Ahky
• Name: transgene insertion 1, Akihiro Yamanaka
• MGI ID: MGI:5662280
• Synonyms: orexin-Cre, Tg(HCRT-EGFP,-cre)#aAhky
• Transgene: Tg(HCRT-EGFP,-cre)1Ahky Location: unknown
• Alliance: Tg(HCRT-EGFP,-cre)1Ahky page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase, Reporter)
• Mutation: Insertion
• Tg(HCRT-EGFP,-cre)1Ahky expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  HCRT (3060)

  Hcrt	(MGI:1202306)

• Mutation details: A 3.2 kb fragment of the human promoter drives orexin neurons-specific expression of EGFP and cre recombinase gene separated by a 2A peptide sequence and followed by a murine Prm1 gene intron and polyadenylation sequence. Two lines were generated with the unnamed line #a having with the highest expression. (J:215679)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	HCRT (human) Summary of all recombinase alleles driven by HCRT. Comparative matrix view of recombinase activities Alliance human HCRT gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:215679 Inutsuka A, et al., Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60
• All: 2 reference(s)