Col10a1^{tm2.1(cre)Ksec}
Targeted Allele Detail

Summary

• Symbol: Col10a1^{tm2.1(cre)Ksec}
• Name: collagen, type X, alpha 1; targeted mutation 2.1, Kathryn S E Cheah
• MGI ID: MGI:5662423
• Synonyms: C10cre, Col10a1-Cre
• Gene: Col10a1 Location: Chr10:34265977-34273081 bp, + strand Genetic Position: Chr10, 18.85 cM, cytoband B1-B3
• Alliance: Col10a1^{tm2.1(cre)Ksec} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122054
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Col10a1^{tm2.1(cre)Ksec} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Col10a1 (MGI:88445)

• Mutation details: A cre recombinase gene and FRT-flanked neomycin resistance cassette were inserted at the translation initiation site in exon 2. Flp-mediated recombination removed the selection cassette. (J:122054)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col10a1 (mouse) Summary of all recombinase alleles driven by Col10a1. Comparative matrix view of recombinase activities Alliance mouse Col10a1 gene page

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col10a1 Mutation: 28 strains or lines available

References

• Original: J:122054 Tsang KY, et al., Surviving Endoplasmic Reticulum Stress Is Coupled to Altered Chondrocyte Differentiation and Function. PLoS Biol. 2007 Feb 13;5(3):e44
• All: 4 reference(s)