Hmgcr^tm2Ishi
Targeted Allele Detail

Summary

• Symbol: Hmgcr^tm2Ishi
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; targeted mutation 2, Shun Ishibashi
• MGI ID: MGI:5662445
• Synonyms: HMGCR^f
• Gene: Hmgcr Location: Chr13:96785475-96807444 bp, - strand Genetic Position: Chr13, 50.65 cM
• Alliance: Hmgcr^tm2Ishi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201488
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a floxed neo cassette was inserted into intron 4 via homologous recombination. The neo cassette is in the opposite orientation to that of the endogenous gene. (J:201488)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgcr Mutation: 62 strains or lines available

References

• Original: J:201488 Nagashima S, et al., Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1824-31
• All: 5 reference(s)