Ccdc80^tm1.1Ftk
Targeted Allele Detail

Summary

• Symbol: Ccdc80^tm1.1Ftk
• Name: coiled-coil domain containing 80; targeted mutation 1.1, Frank T Kolligs
• MGI ID: MGI:5662451
• Synonyms: Dro1^-
• Gene: Ccdc80 Location: Chr16:44913770-44948287 bp, + strand Genetic Position: Chr16, 29.39 cM, cytoband B5
• Alliance: Ccdc80^tm1.1Ftk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216704
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an inverted pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:216704)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Ccdc80^tm1.1Ftk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc80 Mutation: 52 strains or lines available

References

• Original: J:216704 Grill JI, et al., DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice. Mol Cancer Res. 2014 Nov;12(11):1655-62
• All: 3 reference(s)