Sgms1^tm1Jia
Targeted Allele Detail

Summary

• Symbol: Sgms1^tm1Jia
• Name: sphingomyelin synthase 1; targeted mutation 1, Xian-Cheng Jiang
• MGI ID: MGI:5662506
• Gene: Sgms1 Location: Chr19:32100127-32367114 bp, - strand Genetic Position: Chr19, 26.68 cM
• Alliance: Sgms1^tm1Jia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neo cassette via homologous recombination. (J:201497)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgms1 Mutation: 230 strains or lines available

References

• Original: J:201497 Li Z, et al., Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1577-84
• All: 3 reference(s)