Cacna1c^tm2.1Wac
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm2.1Wac
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 2.1, William A Catterall
• MGI ID: MGI:5662550
• Synonyms: Cav1.2^S1700A, SA
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm2.1Wac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216746
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Not Specified) Mutations: Insertion, Nucleotide substitutions Mutation details: An S1700A mutation followed by an FRT flanked neo cassette were inserted in exon 41 via homologous recombination. Flp mediated recombination removed the neo cassette. The Ala substitution for Ser-1700 does not substantially affect native channel expression or distribution, the stoichiometry of the distal (dCT) and proximal C terminus (pCT) in the autoinhibitory complex, or the overall beta-adrenergic signaling, as assessed by phosphorylation of S1928 in response to isoproterenol. (J:216746)

Generation of the Cacna1c^tm2.1Wac allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:216746 Fu Y, et al., Basal and beta-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16598-603
• All: 2 reference(s)